Miscellaneous original manuscripts dated from 1787 to 1825. Survey notes, deeds, plats, and a few letters of varied dates relate to Clark's land interests, the grant to the Illinois Regiment, and the development of Clarksville (Indiana). A few letters, 1793-1794, mention French foreign affairs, Clark's preparations and expenditures for the abortive French expedition against the Spaniards in the Mississippi Valley, and Spanish defense measures. Composing this correspondence are letters of Joseph Fauchet to Clark (1794), Michael Lacassagne to Isaac Shelby (1793), Edmund Randolph to James Monroe (1794), and G. Roulstone to John Sevier (1794). A letter by William Logan to Shelby and a contemporary copy of a proclamation by Juan Ventura Morales, intendant of the Province of Louisiana, concern Spanish-American relations in 1802.

Papers written and/or signed by Clark in this volume include several promissory notes and orders (1787), a plat for land surveyed for him by Robert Todd (1787) several deeds for tracts in the Illinois grant (1788-1789), a letter (1799) on financial matters addressed to Isaac Hite, a deposition (1805) containing an account of Clark's intended expedition against Detroit in 1781, and a letter (1805) to John Breckinridge accompanying a copy of a memorial to Congress requesting ratification of a deed for lands granted Clark by Indians.

Papers, 1810-1818, are primarily bills and receipts for taxes, clothing, carriage and harness, and other expenditures for personal merchandise and services for Clark during his last years. Miscellaneous documents concerning Clark's contemporaries include: an address (1808) by inhabitants of St. Charles District, Louisiana Territory, expressing satisfaction with John Coburn as judge; a survey and plat (1809) for land in Madison County, Kentucky, done by Joseph Barnett for Isaac Shelby; a letter (1825) by Barnett to Shelby concerning Barnett's fiscal problems arising from his service in the War of 1812; and a War of 1812 discharge paper (1815) for Benjamin Bowman.

Other writers of letters in this volume are: Richard C. Anderson, Cuthbert Bullitt, Jonathan Clark, Lardner Clark, William Clark, Martin Durald, John Hardin, Henry Lee, G. Nicholas, James Speed, the elder John C. Symmes, John Taylor, James Wilkinson, and George Wilson. Persons addressed who have not been previously mentioned included: Edward Clark, John Coburn, William Croghan, Gabriel Johnston, Henry Lee, Peyton Short, and Thomas Todd. Among additional signatures to be found on legal and business documents are those of John Baley, Henry Blunt, Alexander Breckinridge, Daniel Brodhead, Abraham Chapline, Marston G. Clark, Andrew Heth, Patrick Joyes, James F. Moore, Samuel Oldham, Jacob Owen, Edmund Rogers, Michael Slaughter, Richard Taylor, Richard Terrell, Robert Todd, and B[uckner] Thruston. A printed handbill (1798), entitled “There is a Snake in the Grass!!!”, warned Kentucky citizens against signing an address to the president in support of the Alien and Sedition Acts.