Series: 1 H (Volume 1)
Scope and Content Note: Mainly original manuscripts, 1775, 1779-1781, pertaining to Indian and military affairs on the western borders of Pennsylvania, Virginia, and Kentucky. Correspondence, speeches, and treaty negotiations feature several prominent Indian leaders: Big Cat, Captain John Killbuck, Jr., Captain Johnny (also known as Israel), Captain Pipe, and John Montour of the Delaware; Half-King of the Wyandot tribe; and Raven of the Cherokee. There are copies of seven letters written to Brodhead by George Washington and of one speech delivered by Washington to the Delaware; the originals were retained in 1846 by the Brodhead heirs. Preceding the manuscripts is a detailed index by Draper.

Series: 2 H (Volume 2)
Scope and Content Note: A small notebook kept by Brodhead, which contains additional correspondence and speeches, 1779-1781, of tribal leaders, mainly Captain John Killbuck, Jr., Captain Pipe, and Raven. One letter by Brodhead was addressed to Daniel Maurice Godefroy de Linctot.

Series: 3 H (Volume 3)
Scope and Content Note: Manuscript copy of a letterbook containing Brodhead's outgoing correspondence, October 1780-December 1781, during his command at Fort Pitt. The transcript was made by Draper in 1846 from the original volume in possession of one of Brodhead's descendants. Among Brodhead's addressees were Benjamin Biggs, Ephraim Blaine, Samuel Brady, George Rogers Clark, John Clark, John Gibson, John Hackenwelder, Edward Hand, Samuel Huntington, William Irvine, Samuel Irwin, Thomas Jefferson, Thomas McKean, James Marshal, Richard Peters, Joseph Reed, David Shepherd, William Shippen, Friedrich W. von Steuben, William Taylor, George Washington, Anthony Wayne, and David Zeisberger.