Correspondence, 1845-1849, principally incoming letters chronologically arranged by Draper, accompanied by a few interviews and other notes. Opening the volume are two indexes by Draper, the first to names of correspondents and persons interviewed, the second to names of persons and events discussed. Most of the papers relate to Brady, Lewis Wetzel, Daniel Brodhead, William Cooke (Cook), William Crawford, Simon Girty, William Thompson, Ebenezer Zane, and to events in western Pennsylvania, northwestern Virginia, and Kentucky from 1774 to 1794, but there are allusions to episodes as early as 1755 and as late as 1815.

A few papers of interest were not specifically indexed: a portion of a ballad on William Crawford's campaign (1782) found in a letter (1843) by William Marshall Anderson; a Brodhead family genealogical chart compiled and sent by J. Romeyn Brodhead (1847); an original page of genealogical records for William Cooke's family clipped from the family Bible and two original pages of Cooke's military accounts for 1779-1780 and 1783, donated (1849) by Jacob Cooke. Also furnished by Cooke were statements and narratives gathered from William P. Brady, John Cooke, Robert Lyons, and James Solomon (Salman, Salaman).

The many other Brady and Wetzel contemporaries for whom there are fewer references in the index include John Armstrong; Henry Bird; Daniel Boone; Hawkins Boone; John Boyd; Joseph Brant; John Brady; Thomas Bullitt (Bullett); John Caldwell; Robert Callender; George Rogers Clark; John Connolly; Cornplanter; John and Thomas Doyle; Matthew Elliott; George and John Gibson; George, James, and Thomas Girty; Edward Hand; James and William Harrod; William Irvine; John Killbuck, Sr.; William La Mothe; Daniel Leet; William Linn; the Iroquois chief Logan; Benjamin Logan; Alexander Lowry; James and Robert Lyon; Robert Magaw; Robert McClellan; John and Samuel McColloch; Alexander McKee; John McKinley; James Morrison; Dorsey Pentecost; Captain Pipe; Oliver Pollock; William Plunkett; David Rogers; John Rose (Baron Rosenthal); James Ross; David Shepherd; James Smith (of Kentucky); Captain Snake; Joseph Solomon (Salman, Salaman); William Trent; Bethuel Vincent; Bezaleel Wells; the Wetzels (Jacob, John Sr. and Jr., and Martin); White Eyes; David Williamson; and Archibald and George Woods. Draper's notes contain selected entries from the journals of the Continental Congress and from John Sanderson's Biography of the Signers of the Declaration of Independence.